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Generic Name: Chlor-Trimeton (chlorpheniramine)

Chlor-Trimeton Reviews

For Allergic Rhinitis "I take diphenhydramine, cetirizine, and the 4-hour version of chlorpheniramine at bedtime every night of the year, whether I have symptoms or not, which is the only combination I have found that will keep me clear enough to live a normal routine without many allergy symptoms. I only take the 'Chlor Tabs' at 4-hour intervals during the day if I am still experiencing allergy symptoms, which include sneezing, coughing, ear discomfort, tinnitus, dizziness, and vomiting (from the dizziness). I can't live without this chlorpheniramine every 4 hours without vomiting from the nausea."


For Allergic Rhinitis "Have used Chlor-Trimeton for many years, 4 mg twice a day, to control allergic reactions to pollen. After trying all other OTC antihistamines, Chlor-Trimeton does the job best, and it's a single-ingredient medicine (not a combination of unnecessary ingredients)."


For Allergic Reactions "I have been taking this for allergic sneezing, itchy eyes, itchy tongue, and back of mouth, allergic post-nasal drip. Very effective. My grandmother told me about it forty-five or fifty years ago. Don't take it if you have high blood pressure. This is an oldie but a goodie. I prefer the short-acting yellow pills rather than the twelve-hour pills."


For Allergic Rhinitis "Have returned repeatedly to Chlortrimeton after taking Zyrtec or Claritin off and on. I get relief for hayfever symptoms without drowsiness and cost is lower. I feel sleepy on the other two meds and the 24 hour dose is not consistent over that period of time. My hayfever is not a severe case with running nose, itchy eyes, and sneezing from Mid-March to May seemingly getting less with age. I'm 69. Have tried the 12 hour dose and find it works consistently for me but prefer the 4 hour tablet."


For Allergic Reactions "I can't use Zyrtec or Claritin because they make my ADHD symptoms worse and counteract my Ritalin medication. This is the only antihistamine that works for me and does not make me drowsy (4-hour version). However, the 12-hour one has made me drowsy."


For Allergic Rhinitis "I occasionally get severe sneezing attacks, cause unknown. They start as a feeling like something tickling my nose followed by a deep intake of breath and a powerful (mostly dry) sneeze. This then repeats about every 20 seconds for several minutes, when it stops, leaving me exhausted and with teary eyes and a runny nose. I found that swallowing a short-acting chlorpheniramine maleate tablet at the first sign, or in between sneezes, is effective at immediately stopping the attack, with no noticeable side effects. I have other chronic health conditions for which I take prescription medications; long term use of antihistamines for me is not recommended."


For Allergic Reactions "I have severe allergies and believe that Chlor-Trimeton has saved my life several times. I have had 10-12 life-threatening anaphylactic attacks over the last 20 years. My attacks usually build slowly, starting with hives, then vomiting and diarrhea, then swelling of my tongue, throat and inner ears. I have found through trial and error that if I can take a 12-hour Chlor-Trimeton in the first 2-4 minutes after the reaction starts, I can stop the reaction all together, or at least get to the hospital without having to use my Epi-pen. I LOVE this medicine for hayfever symptoms as well. Unfortunately, it is getting harder and harder to find the 12 hour tablets."


For Allergic Rhinitis "While it makes me drowsy, gives me dry mouth and can make my scalp tingle/itch it is the only antihistamine that works for my severe hay fever. The 4 hour pills work most of the time and when my symptoms are really bad the 8 or 12 hour ones make my life normal."


For Allergic Rhinitis "I tried this (generic)... normal dose... and it really knocked me for a loop... I could barely get out of bed... alarming! Judging from the ratings. It must work great for others. I AM very sensitive to all drugs and Benedryl works great for me, so not sure why I had such a weird trip on this one."


For Allergic Rhinitis "I have had severe hayfever since childhood and this is one of the few antihistamines that work for all of my symptoms without making me overly drowsy. I'm just sad that they only sell 4 hour pills otc now. I'll have to switch to something else."


For Allergic Reactions "I tried this after trying all others before I got a shot for allergies. I was fine sleeping on it then took it again the next morning and within an hour and 15 minutes I had severe hot flash, got shakey, wired and tired/loopy then nauseated. I just had a second hot flash and the nausea is hanging on too. I will never take it again!"


For Urticaria "24 hours after taking Chlor-Trimeton, 90% of my hives have disappeared. This is the first OTC drug I have taken that has had an effect. I experienced some drowsiness but functioned quite well."


For Allergic Rhinitis "I have used this since I was 5 and first diagnosed with allergies. I am now 78 and still use it. I take 1 in PM and in heavy allergy seasons, I take 1 in AM also. It is better than any other OTC."


For Allergic Rhinitis "This is one of 2 antihistamines that works for me. This is the one that does not make me sleepy."


For Allergic Reactions "The most effective allergy medicine I've found to treat dog/cat/mold/dust allergies. It's too bad you can't find it any more! "


For Allergic Reactions "The 4mg dosage works very well for seasonal allergic reactions."


For Allergic Rhinitis "I took this once for a really bad allergy attack. I fell asleep for about 12 hours during which I had the most psychedelic experience of my life. Wasn't necessarily bad, but whoa, really trippy!"


For Allergic Rhinitis "I have used this product for 60 years. I take one every morning for allergies. I also use it for colds and flu. I rate the generic 10 stars. No noticeable side effects."

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Patient resources

  • Chlor-Trimeton drug information
  • Chlor-Trimeton (Chlorpheniramine Syrup)
  • Chlor-Trimeton (Chlorpheniramine Tablets)

Other brands

Allergy Relief, Aller-Chlor, Wal-finate, C.P.M., ... +7 more

Professional resources

  • Chlor-Trimeton 12 Hour prescribing information

Related treatment guides

  • Cold Symptoms
  • Allergic Reactions
  • Allergic Rhinitis
  • Urticaria