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Generic Name: Zenpep (pancrelipase)

Zenpep Reviews

For Pancreatic Exocrine Dysfunction "Like my mother, I have had a duodenal ulcer, heartburn, and symptoms of EFI and steatorrhea for many years. Otherwise, I don't have pains, and I don't know if I have pancreatitis or CF. Without medicines, I would have 3-5 bowel movements every day, and it is extremely painful when I travel, which I do very often. So I started to take Zenpep, which is very effective without any obvious side effects. When I travel, 3-4 capsules of 20,000 units (the green capsules) with a meal will keep me safe for most of the day. But the worry about the side effects of long periods of usage pushes me to find alternative medicine. Luckily, I found that by chance, the non-prescription 300-400 mg capsules of Nattokinase (3-4 x 2000 FUs) with a meal have the same, if not better, effect to keep me dry for most of the day. Hope it helps anyone who may need it."


For Pancreatic Exocrine Dysfunction "I was diagnosed 2 years ago with stage 4 pancreatic cancer. I have had chemo and radiation, and I am doing very well. When first diagnosed, I was on Creon. I had no side effects, but wanted something a little less expensive, so my oncologist suggested I try Zenpep. It works great, as long as I don't forget and skip a dose. When I skip a dose, all my symptoms come roaring back: gas, pain, cramps, and loose bowels."


For Pancreatic Exocrine Dysfunction "I had unpleasant side effects with Creon, and an abdominal tenderness that lasted almost three years, so I quit taking it. My specialist suggested I try Zenpep. It works for me better and the abdominal tenderness subsided quickly. I have experienced no side effects so far."


For Chronic Pancreatitis "This medication works well for me and I had no side effects. The monthly cost is so expensive!! $1875.72 monthly without insurance! With little to no help from the pharmaceutical company. When my insurance will pay for it it's $240. Monthly"


For Pancreatic Exocrine Dysfunction "Just been diagnosed with pancreatic insufficiency. Was prescribed Zenpep two weeks ago. Started on 1 before every meal and snack. Just increased to two before meals and one before snack. Have seen a big improvement. Praying that it continues. Would like to find a diet program specifically for this condition."


For Chronic Pancreatitis "Started using Aenpep. No side effects but honestly it does not work. I been in pain ever since I started taking it. I take it during each meal and I am in pain. Pertyze is what really works for me but my insurance does not want to cover it :( it sucks that we paid too much for insurance and I have to beg for my meds. Actually is the only one I take. I eat well - I gave up sweets and red meat, coffee, not to many carbs but I hurt. I go on liquid diets for 3 days if not more. As soon as I eat there is my pain again with this pills."


For Pancreatic Exocrine Dysfunction "I was experiencing diarrhea 6 or 7 times a day, had cramps, and a rock-hard stomach and bowels. I had sleeve surgery 8 years ago and my gallbladder was removed about 30 years ago. I was prescribed Zenpep one month ago and feel like a new person. Bloating, stomach pain, and diarrhea are gone as long as I take it with every meal. If I eat without taking it the symptoms return. I am glad I have good insurance as this medication costs $1500 monthly, and I pay $30 for 2 months. It really does work well for me."


For Pancreatic Exocrine Dysfunction "Using Zenpep has made a significant difference in the way I feel having Pancreatic Exocrine Dysfunction (PED). Without this medication I have a difficult time getting through a day without gastric issues."


For Cystic Fibrosis "I've taken Zenpep for most of my life. I take 5 caps with meals and snacks because I have fat in every meal. It works great and the only time I've had an issue is if I had an extra fatty meal and didn't take an additional capsule. I recommend Zenpep to anyone with CF."


For Pancreatic Exocrine Dysfunction "Doctors prescribed Zenpep with meals and snacks. I pay $25 for 250 pills every month for 5 months, and then all my scripts are free for the last 7 months of the year with my insurance. This medicine works wonders. I'm so grateful. It helps with my acid reflux and gas. If I forget to take it, I realize it for sure I will start getting symptoms immediately. The doctor prescribes the max dose, so I will never run out. Forever grateful."


For Chronic Pancreatitis "Zenpep works great for me, however, the cost of the pills is ridiculous!"


For Pancreatic Exocrine Dysfunction "This medicine helped with my EPI symptoms but I experienced side effects such as dizziness, high anxiety, fatigue, and dry mouth, so I am currently looking for another alternative."


For Pancreatic Exocrine Dysfunction "I have been taking zenpep for the past 10 years after having pancreatic cancer. It works great but is very expensive."


For Pancreatic Exocrine Dysfunction "i have been taking Zenpep for 3 weeks and I see no improvement."


For Pancreatic Exocrine Dysfunction "Zenpep Did not do anything for me"

More about Zenpep (pancrelipase)

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Patient resources

  • Zenpep drug information

Other brands

Creon, Pancreaze, Pertzye, Viokace, ... +3 more

Professional resources

  • Zenpep prescribing information
  • Pancrelipase (AHFS Monograph)

Other brands

Creon, Pancreaze, Pertzye, Viokace

Related treatment guides

  • Pancreatic Exocrine Dysfunction
  • Chronic Pancreatitis
  • Cystic Fibrosis