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Generic Name: Ezetimibe Tablets

Brand Name: Zetia

Zetia Drug and Medication User Reviews

This drug is so terrible, no one should ever take it! Beware! The side effects were so debilitating, I seriously felt like I was 80 years old. The side effect started slowly, and progressively got worse. I didn’t realize it was the drug at first, and thought maybe I had lupus or ruemitoid Arthritis. I had a strange foot pain that got worse as the weeks went by, to the point where standing for any length of time felt like I was standing in rocks. Then it was hip pain and neck pain. Also had swollen joints especially in my hands and knuckles, they hurt so bad. It took over 6 weeks for these symptoms to disappear. I can finally say after 2 months I feel like myself again. I didn’t realize how much strength I had lost. I am a very active person, and I want able to exercise like usual. For a while I was scared that these side effects were permanent! So thankful they weren’t. On a side note, statins gave me very similar issues, but my pharmacist recommended Citrus Bergamot and I am happy to say in 3 mo. It lowered my cholesterol 58 points!! No side effects! Wonderful alternative to these horrid drugs!


I have been using the Zetia generic for four months. My cholesterol and triglyceride numbers improved and are the best in a few years. I cannot tolerate statins that well (did ok many years ago). I am now experiencing greater muscle weakness and fatigue. Before my visit, all my levels were normal within limits except my LDL, PA recommended stopping Zetia and starting Repatha. We'll see how it works, hate injecting my body. I am stopping the Zetia muscle pain pill.


This drug is so horrible, i cannot believe that Dr’s prescribe this drug! I was on it for 8 weeks. During this time my quality of life deteriorated. When I finally realized that the drug was the cause of all my issues I felt like I was 90! I had this constant pain in my foot, fatigue, achy swollen joints, especially in hands neck and hips. I could hardly work in week 7, I had to take 4 alieve to survive a day of work. I felt terrified that the symptoms would not improve after reading the reviews on wed md. It has taken 2 full weeks for me to feel like myself, and I am so thankful! I was worried I was dealing with permanent damage from this drug! BEWARE IF ZETIA!!


Within several days of taking this med, I could barely walk. Extreme lack of energy.


I've taken Zetia for ~ 2 years. No side effects to note. It helped bring down overall cholesterol from about 199 to 165...and brought down LDL to about 105. I started taking Rapatha4 months ago...my total cholesterol is now 87 and my LDL is 20 (down from 105)! I've been on statins for 25 years and my current numbers have never been this low. Talk to cardio next week...plan to stop taking Zetia.


I also cannot tolerate statins. My Dr. started me on Zetia (Ezetimibe) 2 months ago. I can now barely walk. Pain in legs, ankles and feet. Fatigue and mild depression. The side effects are debilitating. Stopping this drug immediately.


After two weeks I started feeling jittery and anxious. I had constant head aches and at inconvenient times an urgent feeling I would void my bowels. I also felt depressed. I did not feel the exquisite pain I get with most statins (Livalo excepted), I coughed more than usual which I read happened to some others. My Cardiologist responded that mine were not normal reactions to Zetia, but after reading these reviews I'm glad I stopped taking it yesterday. My head still hurts. I hope the reactions subside soon.


I have been using the Zetia generic for four months. My cholesterol and triglyceride numbers improved and are the best in years. I cannot tolerate statins. I am now experiencing muscle weakness dizziness diarrhea nausea and fatigue. Last night I had a significant breathing problem although that is not listed as a side effect. I plan to stop taking it.


No tolerance for statins, so...one month on 5 mg of Zetia daily had brought cholesterol down to 167, from 234 but the side effects are overwhelming. Joint/muscle pain/cramping has cut my activity level WAY down; either stuffy or continuous runny nose and dry hacking cough; fatigue, constant chills. Have felt like crap entire time. Can't say I'd recommend the drug and will most likely quit taking it.


I’ve taken Zetia for 1 year (with a statin) for FH. LDL plummeted. I thought EXCELLENT! Dr suggested COQ10 for new muscle & back pain. This was tolerable. I recently began process to be a kidney donor and failed the first round of testing. My liver enzymes were 3x normal and my kidney output is insufficient. I researched, this is a rare side effect. Dr confirmed not typically seen, I stopped Zetia 6/11/21. Back pain has 100% diminished. Blood work again in two weeks. I will be going to a Lipid specialist next.


Very effective bu PAIN in every joint, extremity, soft tissue of my entire body. I literally cannot move without assistance. I was very active before and am now almost unable to get out of my home....I have decided to stop taking it for a week or two and see if the pain diminishes. If so, I will contact Dr. for what to do next. I cannot live like this as I have genetically high triglycerides.


I have very high cholesterol-- over 400 when I was only 35 and weighed 110 pounds. Barely controlled for years on statins. I'm now 60. When my new doctor doubled my statin and saw no change in lipid levels, he prescribed Zetia in addition to the statin. I've been taking this drug 3 months now and my total cholesterol dropped 50 points. I've never been in the "normal" range before! I've experienced no side effects.


After taking zetia for 6 weeks, severe joint pain in knees which were both replaced in 2012/2013.


I have been on zetia for one week and during that time I have experienced the most severe stomach pains with diarrhea and vomiting. The reason I changed med was the statins were damaging my legs and had quite severe pain. I am at a place where I can't?t tolerate either.


After about 6 months or so of taking this drug (ezetimibe) I started experiencing constipation and brain fog. For past 4 months this has become serious depression, brain fog, memory loss, loss of appetite, constipation (leading to fissures), anxiety. I am 56, with low cholesterol and otherwise a healthy male, healthy diet, exercise, I feel I am in a mid-life crisis. Never in my life have I ever felt like this. It's effecting my entire self. After much online research I've uncovered that this drug is known to cause all of these side effects. After reading other comments on here, I now know this to be the root cause of all of these issues. I won't be taking this drug any longer. Thank you all for sharing your experiences. This was very helpful.


Within three days had extreme muscle spasms, the same response I got from two statins, very painful


Statins dont like me so I started Zetia and (Niacin B3 the kind that flushes) and after 3 months my Cholesterol went from 282 down to 143 LDL was 215 down to 85 HDL 46 down to 38 Triglycerides from 103 down to 100. It works for me with very little side effects.


I have been on all the statin drugs and they caused severe muscle weakness and brain fog. My Dr. put me on Zetia and my cholesterol is almost back to normal and my triglyceride level came down to just above normal and that is the first those numbers have decreased ever. I have been on Zetia for 2 years now and don't seem to have any side effects. I am 76 years old.


I cannot take statins and my cholesterol is hereditary. My doctor the last several visits suggested I take zetia. 8 days into zetia my middle toe swelled up and got all red and my left leg hurts so bad I almost had to go to the emergency room I couldn't stand it. I took myself off the drug and slowly the redness and swelling in my toe subsided and my leg pain stopped however I lost the nail on my middle toe after this incident.


I have been on zetia for years. I do not get muscle cramps or weakness but I am concerned about it affecting stomach or bowel. Of course people do not admit adverse side effects of a drug but I am convinced it can hurt you in the long run.