Generic Name: Skyrizi for Crohn's Disease (risankizumab)
Skyrizi for Crohn's Disease Reviews
"I'm in a clinical trial taking Skyrizi to treat my Crohn's disease symptoms. I've been injecting the medicine every 8 weeks for at least the last two years and I'm happy to report I've been in remission and symptom-free. The downside: it has wreaked havoc on my immune system and I get sick with everything to the extreme now. My body cannot fight off anything I'm exposed to. I've also gained a major amount of weight: 30 pounds in one year! My doctor says it's normal because I'm not in malabsorption anymore, but it's as if my metabolism has slowed versus absorbing. I don't eat any more than usual, yet keep gaining weight."
"This drug has been an absolute miracle and should be the first-line treatment for many Crohn's patients to speak to their doctor about. After 13+ years of different medications, this is the only one that has given both symptom relief and also a 90% improvement in inflammation/lab markers. Honestly, it delivers what the commercials promise. However, it is very expensive and critical to have good insurance. The on-body injector is the easiest and most pain-free injection method I have had. It took about 6 months to really see marked results in labs. In my journey, I've tried Humira (became ineffective), all the pill/foam/suppository options (zero improvement), Entyvio (worked some but the infusion center schedule was difficult with my work travel), lastly Stelara and Cimzia, which caused neurological issues including a tonic-clonic meltdown with Cimzia specifically. I cannot think of any side effects to date other than no longer looking for a bathroom constantly. Nothing is truly everything."
"I have had the two infusion doses. No side effects except my anemia is worse. Which may not be related. It is almost like I don't have Crohn's anymore. I was doing well with Inflectra but developed antibodies to it."
"Previously on Entiviyo until efficacy declined and symptoms came back. Skyrizi chosen due to past history with CNS lymphoma. Symptoms disappeared after initial dosing of Skyrizi. Just had my second 8-week interval self-dosing and still no Crohn’s symptoms. I have had a bout of pneumonia (not new for me) while on Skyrizi. My immunoglobulin G was just tested and is slightly below acceptable range. Self-dosing is easy to do and have had no problems."
"Skyrizi caused serious liver damage to me! After only being on this medication, for the initial 3 infusions, it has caused severe hepatic steatosis."
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Related treatment guides
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