Generic Name: Sunosi (solriamfetol)
Sunosi Reviews
For Narcolepsy "I have been diagnosed with Idiopathic Hypersomnia - a VERY close relative of narcolepsy without cataplexy. I started on Sunosi 75 mg per day. That did nothing. I only experienced relief at the full 150 mg dose. Effects start about 1 hour after I take it, shorter on an empty stomach. When I take the 150 mg dose, I am able to focus and don't feel 'jittery' or agitated at all. It's a very nice medication for that reason. I find it's much more gentle than caffeine. The downside - this effect only lasts 3 hours. On the fourth hour, I start to 'crash' and get very tired. I cannot resist a nap. This is counterproductive but common with every stimulant. So, my doctor is trying me out on a low 5 mg dose of the short-acting form of Adderall to 'cover' me during this crash. I will report back on the combination soon. Hope this review helps someone!"
For Narcolepsy "I started Sunosi 2 weeks ago for Hypersomnia. This medication may be life changing. Before taking Sunosi, I was miserably dragging myself out of bed every morning, not knowing how I would make it through the day. My daily life consisted of working, constantly yawning, craving one more minute to close my eyes, napping 3-4 hours every day after work, and sleeping all night. Then, I would sleep the entire weekend away. A terrible 'existence.' Since starting Sunosi, I wake up much easier, my constant yawning has decreased by about 90%, and the best part is my daily 3-4 hours naps are disappearing! A couple days I’ve taken 2-hour naps (huge improvement), but I’ve also gone many days with NO naps!!!! I start to get tired around 8 pm and head to bed almost like a normal person. I do get a slight stomach ache at times, but eating usually helps. Thank you, Sunosi for HOPE!"
For Narcolepsy "I started at 75mg at 7 a.m. By 12:30 p.m., I crashed and could barely stay awake. I’m now taking 75mg upon waking and 75mg two hours later. The best way I can describe it is that I’m awake but not overly motivated to do anything, and I’d rather be sleeping. However, it’s the best option I have at this point because nothing else seems to work."
For Narcolepsy "I got the free trial of 15 Sunosi pills. When I started using it, I didn't feel any better, still felt very tired. On the 2nd day of use, I started getting a bad headache and still felt really tired. I also checked my blood pressure, it was starting to get higher than normal, and my stomach was starting to bother me. After the 3rd day, my stomach got worse, still had a bad headache, and blood pressure was getting higher, some slight chest pain. So after that, I stopped taking it, and now it's been a week since I have been off of it, and no headache or stomach problems, and blood pressure is down. The only thing I know is all the drugs that I have taken for narcolepsy had bad side effects, and they all seem to be a bandage to fix the problem. I hate all of these meds because no one knows what damage you're doing to your body taking these meds, that's why none of this stuff is good for you."
For Narcolepsy "I have had narcolepsy and been on Adderall or Nuvigil for 20 years. I did the 75mg to 150mg and at 12 weeks, I thought my life has changed. Then at 16 weeks, I come home from work more exhausted and tired than I can remember, as if I’m not taking anything. I’m withdrawing from life - to sleep by 7pm. Unless I throw Ritalin at it, which I’ve never had until now (odd?). I’m worthless by 5. Then I’m up at 3:30 or 4am. Let me off the roller coaster ride."
For Narcolepsy "Sunosi 75mg a day has changed my life. I’m awake and not sleepy all day - it even seems to help me wake up in the morning. I don’t get the crash I did with Adderall. It’s a much more natural awake feeling. Even spending an entire day in front of a computer, I didn’t get sleepy."
For Obstructive Sleep Apnea/Hypopnea Syndrome "I've been taking Sunosi 75 mg for over a week now. The first couple of days, I didn't notice any difference. Normally, I am in bed by 7:30 or 8 PM at the very latest because I could not stay awake. I yawn all day long and am just ready to drop. I can never get enough sleep, even if it's 12 or more hours. On the third day of taking Sunosi, I had to catch myself because I looked at the clock, and it was 10:30 PM. I was not ready for bed, but I forced myself because I knew I would pay for it in the morning. I woke up before my alarm went off at 4 AM. It has been the same every day since. I still yawn occasionally during the day, but I am able to stay up much later and wake up easier in the morning. Thank you, Sunosi!"
For Narcolepsy "I didn’t have a lot of high hopes for Sunosi, I thought it would be very similar to Nuvigil/Provigil. I tried 75 mg, we jumped up to 150 within two days. The doctor even had me take an additional 75 mg to make it to 225 mg, which is over the recommended dose, and I still felt absolutely nothing on any dosage. It’s labeled as a norepinephrine, dopamine reuptake inhibitor, or NDRI. There are several already on the market, but their use is for antidepressants. However, an NDRI, according to all the medical research I’ve seen, would take weeks to reach full effect. I don’t understand how Sunosi can possibly block the reuptake of dopamine and norepinephrine within 20 to 30 minutes to achieve the effect needed. So I hope this helps somebody, make sure you get free samples or get it covered by your insurance. The manufacturer also offers a discount card which makes it only $8.00. Do not pay cash for this medication until you’ve tried it."
For Narcolepsy "I was just diagnosed in May 2020 with narcolepsy. I was given another drug that worked at first, then stopped after about 2 months. So, my doc prescribed Sunosi. It did not help at all. I called him, and he told me to double my daily dose, so I did. Still don't feel anything, still am exhausted, no energy! I've been having a heck of a time with my insurance not wanting to fill it, then it doesn't work when I do get it finally. Disappointed."
For Obstructive Sleep Apnea/Hypopnea Syndrome "I've been taking Sunosi for around two months for OSA. I started at 75 mg daily, and I've been taking 150 mg for about two weeks. It is probably important to note that I also take 250 mg of Nuvigil and 20-60 mg of Adderall daily as well. I started the Sunosi with the goal of stopping the Adderall. My diagnosis is severe OSA with excessive daytime sleepiness. Narcolepsy was ruled out, although I experience restless legs and occasional sleep paralysis. I hold my breath in my sleep and wake up feeling like I am suffocating because I cannot force myself to breathe. I have used a CPAP regularly for more than 10 years, and the data shows that my sleep apnea is well controlled. But even so, I sleep between 15 to 18 hours per day. Sunosi was ineffective at 75 mg. At 150 mg, I am awake but too fatigued to do anything. It has caused anxiety, headaches, excessive sweating, nausea, and diarrhea."
For Narcolepsy "I’ve been on and off Sunosi for 6 months. I’m still tired, and the side effects are not great. The extreme dry mouth and clenching my jaws are driving me crazy. Going to see if my doctor can give me something else to take."
For Narcolepsy "I was given 75 mg Sunosi for my narcolepsy. On the positive side, I can tell the difference in energy, concentration, motivation, and productivity, and there is a decreased need for a midday nap. Negative: this drug causes major heart issues. I have atrial fibrillation, and I cannot take this medicine regularly as it increases my heart rate to 120 and raises my blood pressure. However, I try to take it once in a while if I have a commitment or something important to do, like running errands or needing to go somewhere. I am on Xyrem 4.5 for narcolepsy with excessive daytime sleepiness, which, although it helps me sleep about 6-7 hours, no longer helps me wake up refreshed as it did the first time I tried it. I also take Doxepin to sleep longer, but it leaves me feeling too tired the next day and counteracts the effect of a good night's sleep. I take a nap in the afternoon, except on the day when I take Sunosi."
For Narcolepsy "Sunosi is very disappointing so far. Disturbing my husband's sleep more, as he is having more awakenings. Not seeing much difference after taking, except more irritable. Also, cannot seem to stay awake for long at all during the day, and when he is awake, no motivation, fatigued. So far, does not look like the drug for him. Better on older stimulants."
For Obstructive Sleep Apnea/Hypopnea Syndrome "First day took half of 75 mg. Went home and took a nap. Woke up and took the other half, still went to bed a few hours later. Medicine had no effect on me. Got up the next morning, took a whole 75 mg in the morning. Felt sleepy on my way to work an hour later. Felt okay through the morning at work, but when the afternoon came, it all changed. I got sleepy and very agitated. I felt like I hadn’t slept in 3 days, but my eyes were forced open. I felt terrible and was very angry and bothered. Tried a whole again the next morning. Here I am laying on the couch ready to take a nap 5 hours later. I feel like the medicine has no effect whatsoever other than annoying me and keeping my eyes open when my body desperately wants sleep."
For Narcolepsy "So I’ve been taking the 150 mg for about five months now. At first, it seemed like it was helping me, and I didn’t get the crash with the Adderall. At this point, I’m not sure if I still feel that way. I still get excessively tired, and I am extremely moody. I don’t have any motivation at all, and I feel as though my chest is tightened around hour two, and I’m almost in a daze/fog. The depression associated with the narcolepsy seems to be getting worse. I definitely think I need to change it. I was never on Provigil/Nuvigil since I was diagnosed right when this drug came out."
For Narcolepsy "I shared the experience of another person that added a review. I was so excited the second day I was on this medicine because I wasn't tired and didn't have any other side effects. Fast forward two weeks, my chest erupted in hives, and I went to urgent care. They put me on a steroid pack for six days. While I don't have a rash any longer, I'm extremely itchy, have pins and needles on my face, tongue, throat, and eyes. I stopped the drug and am on another round of steroids in the morning and Zyrtec at night per my primary. I also had an increasing heart rate, which made me very uncomfortable. That has generally subsided."
For Narcolepsy "Started with 75 mg for about 5 days and then went up to 150 mg. At first, the medicine seemed that it would work once I got used to the side effects and learned how to take it so that I was awake during the day but that it didn't keep me up at night - I was more awake during the day without really thinking about it. Unfortunately, on about the 7th day of taking Sunosi, I had a horrible 'drug eruption' reaction. I went to urgent care, and they put me on steroids to help with the swelling, and I obviously stopped taking the drug. My face completely swelled up and developed a horrible itchy rash all over my body. It has been over ten days now, and although things are getting better, I still have an extremely itchy rash over most of my body. I am not allergic to any other medication and have never had a reaction like this. The other side effect I noticed during the week of taking it was lack of appetite."
For Narcolepsy "I have been reading these other reviews, and other than the people with allergic reactions, I don’t feel that most of them are giving the medicine enough time to work. I have been on Sunosi for three months now, and the side effects have changed over time. Everyone knows it can take your body some time to adjust to medication. I have been diagnosed with obstructive sleep apnea with excessive daytime sleepiness, but my neurologist thinks I do have narcolepsy, too. He started me out on 75 mg, but I didn’t notice any difference, and after two weeks, he doubled it to 150 mg. One side effect I had at first was agitation, but I rode it out, and after a while, I noticed that I wasn’t feeling agitated anymore. Also, the way my body reacted to the drug changed over time. At first, I would crash around lunchtime and early afternoon, but wake up during the evening. Now, the afternoon crash is a lot better. This is a great medication, but you’ve got to give your body time to adjust."
For Narcolepsy "I was put on 150 mg Sunosi for excessive daytime sleepiness. I took one day, and I was awake, but not motivated and could not focus on anything or be productive. I have been on Provigil for many years, and they said this medication was better than Provigil. I hope it works for others."
For Narcolepsy "I’ve been on 150 mg of Sunosi for two days, and I can barely stay awake. I was previously on modafinil, but after years of taking it, it stopped working for me. I am not impressed with Sunosi at all, and will be looking for something else until I can go back to modafinil."
For Narcolepsy "75mg taken in morning I usually expect my medication for my narcolepsy to take effect after about 1-2 hours depending if I eat with it however at 75mg I can’t really say if I feel it working I still feel tired during the day even though I don’t fall asleep. I definitely feel I would fall asleep if I didn’t preoccupy myself like playing a game on my phone to keep myself from closing my eyes. If I did close my eyes I feel I’d be likely to fall asleep especially if I had a busy day or a bad night with little sleep."
For Obstructive Sleep Apnea/Hypopnea Syndrome "Sunosi doesn’t work for me. It’s been about a week at 150mg. It makes me crash hard at the end of the day (around 4pm). At the end of the day, I’m more tired than if I didn’t take it at all. I’ve been waiting for this “miracle medication “ for a few months and I’m disappointed. Nuvigal was great but it stopped working ."
For Narcolepsy "I had spent months just eating enough to live, Going to the store was too much effort. Sleep, depression, not getting up or out, the world will forget you exist. My Psych added Sunosi and half dose of one of the drugs that had faded results years ago, 6 weeks ago. It was about 2 weeks before I was getting up and dressed most days. Then every day. (TBI Survivor 2004) fatigue, sleep, and on task energy has been some of my longest battles after injury. Sunosi has helped lift me from a 6 or 8 month very deep slump. It has worked where other drugs did not. [ Many of us react differently to each drug, this one works well for me.]"
For Narcolepsy "I want it to be affordable because people like me who have Narcolepsy are physically struggling to go to work. How can 30 pills worth of $700 bill work for a person like me? I can’t even work to stay awake. Change the price and you will get the supply and demand you want; considering that every insurance company looks at the dollar bills and not as human. Fix this now."
For Obstructive Sleep Apnea/Hypopnea Syndrome "I have OSA and use a CPAP. I also have severe RLS which is treated with oxycodone. I am constantly tired. I heard about Sunosi and asked my doctor about prescribing it for me. She first wanted to try modafinil. This did absolutely nothing and actually made me feel worse from the side effects, which I found later that oxycodone and modafinil have “major” interactions. (Not sure how my doctor or the pharmacist dropped the ball on that one). So finally my doctor agreed to try the Sunosi. Started at 75mg, felt absolutely nothing good or bad. After several days went up to 150mg, still no improvement in my sleepiness after several weeks of trying. I’m now weaning off ( as recommended by my doctor) since the medication did nothing for me, and I feel awful. I’ve been having panic attacks and my heart rate has been elevated and I also feel achy all over! Not sure if anyone else has had this experience trying to get off the medication but I feel worse than ever!"
More about Sunosi (solriamfetol)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- FDA approval history
- Drug class: miscellaneous central nervous system agents
- Breastfeeding
- En español
Patient resources
- Sunosi drug information
Professional resources
- Sunosi prescribing information
- Solriamfetol (AHFS Monograph)
Related treatment guides
- Narcolepsy
- Obstructive Sleep Apnea/Hypopnea Syndrome
