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Generic Name: Trilafon (perphenazine)

Trilafon Reviews

For Psychosis "I had a similar experience. Tremors in hands (not really noticeable to someone watching unless they were looking for it), but relief from the delusions I was experiencing. My problem has been going on for over 16 years, so I anticipate it will not magically disappear (and it didn't), but the clarity of thinking I experience with this medicine really helps me."


For Bipolar Disorder "I have been on Trilafon for 2 years now. Mostly, I liked it at first because it brought me back to earth when I was over-anxious. I have lowered my dosage since then, and I thought it was doing me well, but I have been having neck problems lately and have realized that this is a side effect of Trilafon called extra-pyramidal syndrome that damages my posture area, so no matter how hard I try, I can't regain a good posture."


For Psychosis "I was prescribed this in 2014 when I was 13 years old. It gave me permanent side effects. They include, WIDENED WAIST that I cannot shrink, weird movements with my face I have to do patterns in every single part of my body, it made me eyes look opposite ways which now in 2019, is still there but not as bad. It made me gain weight, it made my skin dull and grey like I was dead. I wish I could include a picture. It made me have a permanent tremor, too. It's a horrible drug. My posture now sucks and I can't breathe if I try to fix it. I can no longer tan after I took it. I was tan my whole life now my natural tanning peels off and I am white I was never white"


For Psychosis "I had a very bad experience with perphenazine. I ended up with severe joint pain, difficulty breathing, chest pain, weird spinning sensation in my face on the right side of my nostril, on my forehead and on the right side of my temporal area. I had difficulty urinating and horrible insomnia. It has been well over 6 months since taking up to 12 mg for only a few ( about 2--4 days) and I am still having problems. I started on only 4 mg back in Dec 2013 and took the same dosage up to Mar 2014. I stopped because I could barely urinate. Then, I started have weird movement as stated above in my face, but not as bad as the movement when I took 12mg. The, I was told that I needed to start back on this drug for the movement to disappear."


For Psychosis "This really helped my PTSD and major depressive symptoms. Much better than seroquel. Movement side effects when I got up to 12 mg a day. Lowered my dose back down to 8mg a day and the movement side effects went away."


For Psychosis "Great drug! Helped get rid of my delusions. I’ve been on it 5 years now and the dose I am taking 8mg at night. Also take 1mg cogentin to prevent the shakes. Risperal and seoquel didn’t help me. Thankful for this drug. Saved my life."


For Psychosis "I was put on this drug, erroneously I believe as I was only suffering a major depressive episode, in 1974. From that time until I went through menopause in 1997 (23 years) I had the side effect galactorrhea. I was never pregnant or post breastfeeding during that time and took no other medication with that side effect."


For Bipolar Disorder "Helped stop hallucinations."


For Psychosis "Not bad! I'm taking other meds as well. I recommend everyone gives it a chance before judging to harshly on this site."

More about Trilafon (perphenazine)

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  • Drug class: phenothiazine antiemetics
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Patient resources

  • Trilafon drug information

Professional resources

  • Perphenazine monograph
  • Perphenazine Amitriptyline (FDA)

Related treatment guides

  • Psychosis
  • Nausea/Vomiting