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Generic Name: Trudhesa (dihydroergotamine)

Trudhesa Reviews

For Migraine "I've been using Trudhesa for about one year and it works! Previously used Imitrex/sumatriptan nasal spray for 15+ years but that went right down my throat and sometimes the headache came back. The Trudhesa device does the work - don't need to inhale or tilt your head back. If the first spray doesn't work in 45 mins, I take another 2 from the same vial and I'm set. My neuro explained that it's such a little amount of DHE and it's safe."


For Migraine "Used one time during a migraine episode (7 out of ten pain), the pain diminished in about 10 minutes to a 2-3 out of ten. The device/setup is a bit time-consuming but easy to use. However, side effects started immediately with dizziness, unwell physical and mental sensation. As well as severe burning in the nasal cavity/sinuses. I experienced nausea and abdominal pain (7 out of ten) for the next 2-3 hours. I took 25mg of Phenergan, yet I still projectile vomited 2 hours after the nausea began. I also experienced tingling in my arms and hands with mild to moderate discomfort. My sinuses became congested within the first hour and lasted the remainder of the night. I was unable to breathe through my nose until the following day. The next morning I awoke with mild nausea, diarrhea, fatigue, and a malaise feeling. Yes, the migraine dissipated and did not return the next day, but the side effects are too much for me to bare. I have had better experiences with other migraine medications, like Nurtec ODT."


For Migraine "Within 4 hours of using Trudhesa I had chest pain and my watch alerted me of heart rate under 40 for greater than 10 minutes. I suffered bradycardia and pain, my heart rate has remained low and I’ve spent thousands in hospital bills and medical tests. And I still had a headache."

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Patient resources

  • Trudhesa drug information
  • Trudhesa nasal

Other brands

Migranal, D.H.E. 45

Professional resources

  • Trudhesa prescribing information
  • Dihydroergotamine (AHFS Monograph)

Other brands

Migranal, D.H.E. 45

Related treatment guides

  • Migraine