Generic Name: Trintellix (vortioxetine)
For Depression "I was so far down I was ready to give up. I begged my Dr for help, I cried all day every day, I couldn't get out of bed, I thought I was going to die. I prayed, I begged for someone to please help me. My husband and kids didn't know what to do. I was in a black hole, but he kept me on the same old antidepressants. I decided to change doctors, I don't believe for one minute that my old doctor cared if I died. So I went online and found a different doctor, and my new Dr put me on Trintellix. Along with Ketamine treatment. I finally was able to get out of bed, to be able to go to work, cook a meal, not cry every day. It was like I woke up. I truly believe if I hadn't changed doctors and found Trintellix I would not be here today. It's the best medication in the world for me! This medication saved my life."
For Depression "This medication has been a lifesaver. I have tried so many different antidepressants (Prozac, Zoloft, Wellbutrin, Lexapro, etc.) and none of them have worked as well as Trintellix. My 'episodes' have disappeared and I finally feel stable, which has allowed me to make important life decisions that I was always too fearful to do. In the past, I felt that I couldn’t trust my emotions because they felt too extreme. After years of constant sadness, worrying, and lack of motivation, I am relieved to feel like my normal self. I had maybe 3-4 days where I felt nauseous, but overall, I do not experience this side effect. I have been on 10mg for approximately one month, and it’s been the most joyous month I’ve had in years. I highly recommend this medication."
For Depression "Four weeks on Trintellix and I feel it is working better than any other antidepressant, mostly due to the fact that the side effects are almost non-existent. I am not noticing my eating habits going through the roof, and I don't have that apathy that I've had with almost all other drugs. It was tough for a couple of weeks until my digestive system got used to Trintellix, but now it is working great. I am just starting to enjoy some of the things I used to love. I am no longer mourning the two deaths in our family a year ago. I have nothing but good reviews for Trintellix. I am on 10 mg."
For Major Depressive Disorder "I'm bipolar 2 and have suffered with major depression for so many years now. I have tried most antidepressants and with no luck! My latest bout lasted 3 very long years... 3 very dark years. I had enough of fighting my own brain and decided that I should see my psychiatrist because I knew in my heart that this wouldn't get better and I would wake up in 3 more years worse and wondering where my life has gone. I did it and I've been on lamictal and Trintellix for a few months now. I promise you it's the best result I have ever had. Zero side effects unless you go up in mg too fast. So far? I'm happier. I have more motivation. I have more clarity. I shower daily - most days lol. And, more importantly, I have hope. Not all meds are meant for everyone and they are very different just as we are as people. Please don't give up if Trintellix isn't 'Your drug'. Blessings over you all, Pandora."
For Depression "Unlike other antidepressants I have taken, Trintellix gave me immediate relief. Within a few hours of taking it, I could feel a weight being removed from my shoulders. I can't explain it... I'm just thankful."
For Depression "The day I took Trintellix, I felt my throat open up. I felt the effects of it almost immediately. It has changed my life. I have taken other antidepressants and they only made me feel so terrible with vomiting and feeling so down. I was hesitant to try anything else, yet my amazing doctor, who I trust dearly, told me how effective Trintellix has been for anxiety, although it is commonly used for depression. Changed my life. Highly recommend. P.S. My doctor reassured me that Trintellix would be the right drug for me if I had no side effects. That’s why I trusted to try it. If you’re having side effects, it’s not the right drug for you, and you should commit to trying other meds until you find the right fit. The right fit may take several tries, yet I promise and can reassure you, it will change your life for the better. Trust in the process and commit to finding the right fit with the help and surveillance of your doctor. You won’t regret it."
For Major Depressive Disorder "I have had severe anxiety and depression. OCD and social anxiety... over 30 years. Trintellix has taken the edge off and allows me to relax and feel carefree. This is saying a lot because I was living between sadness and the terror of anxiety of the absolute worst kind. Trintellix has provided relief that I didn't think was possible. Thank you."
For Depression "I have had constant anxiety my entire life. I am 40 years old now. Zoloft helped with my agoraphobia, anxiety, panic attacks, and general feelings of daily anxiety. However, about 2 months ago I started feeling something that I'd never encountered in my life: depression. I had absolutely NO motivation to get out of bed, go to work, be around anyone, and felt horribly uncomfortable/sad daily. My doctor recommended Trintellix. I, obviously, have still been weaning off of the Zoloft. (I'm now on 50 mg of Zoloft and 10 mg of Trintellix.) Good luck to anyone out there who reads this... Know that you're definitely not alone or 'crazy'! People who have never had anxiety, depression, or other mental illnesses will never understand what you're going through. What may seem extremely easy for them to do daily can be so tiresome, exhausting, and unexplainably difficult. Keep trying and don't ever give up on yourself!! Life can and will get better... Even if it means waiting over 30 years!!"
For Depression "I was prescribed Trintellix for my GAD and MDD. I’ve been taking 5 mg for a week now. The first two days I experienced nausea, and I am still experiencing headaches and some fatigue, which I suspect will go away in the next week. So far, I am very pleased with Trintellix. I have already begun to see a reduction of my GAD and MDD symptoms. Before Trintellix, I tried Paxil, Zoloft, Lexapro, Pristiq, and Effexor, all of which gave me horrible side effects and left me feeling very zombie-like. So far, no zombie-like feeling with Trintellix. I will post an updated review when I hit the 4-week mark. I’m hopeful that my GAD and MDD symptoms will continue to improve."
For Depression "I've been suffering from major depression since I was a teen. I've had issues with panic attacks, severe anxiety, obsessive-compulsive disorder, and just about everything else. For years, I've been on Lexapro because it's the only medication that would work for me. The side effects of Lexapro, however, were horrendous! The side effects outweighed the benefits. After a few months of discussing it, my doc switched me to Trintellix. I have done a 180! I feel so much better that it scares me! I haven't felt this good in so long that I forget how to act. I'd say it's a miracle, but I know it's no miracle... it's science! After a lifetime of depression, I'm excited for the future."
For Major Depressive Disorder "Excellent drug for my MDD/anxiety. Here's what I suggest: Start slowly. Cut a 5mg in half, let your body adjust for 4 days. Then go to 5 mg for 4 days. Then to 10 mg. Stay on it. Let it do its work. It has dramatically lifted my depression and anxiety and has helped me enjoy life, interacting with friends, etc. It seems to hit all the right brain receptors for me. I went up to 20 mg but didn't need it, 10 mg was enough and there are fewer sexual side effects at 10 mg. Low dose is enough to get my neurotransmitters functioning - no need to go higher. It might have taken me a little longer to get there due to the slower titration, but definitely worth it. Doc said to be patient and that climbing too high too fast will increase the risk of nausea, etc. Since I didn't have that, I'm thinking he is right. Good luck, I hope it works for y'all like it has for me!"
For Depression "I started Trintellix 2 months ago for anxiety/depression. I've been on Wellbutrin, which helps my mood and can counteract some sexual side effects, so I’ve stayed on it, but it hasn’t really helped my anxiety. I’ve been on Zoloft, Lexapro (horrible experience), and Cymbalta, all had side effects I ultimately found unlivable. Honestly, starting Trintellix was rough, but if you can manage, stick with it! I had pretty bad nausea but only threw up once within the first few days of starting, and I started super slow and low. No other side effects, and this is the first med that has not affected my sexual function. My anxiety is lessened, and I feel hopeful. The daily nausea has gone away, although I’ve noticed I’m more prone to motion/car sickness, but my doctor gave me Zofran for that. So far, this Wellbutrin/Trintellix combo is the best I’ve found for me. P.S. Go through their website to get your Rx card to help with costs, it helped my price tremendously."
For Major Depressive Disorder "Trintellix has changed my life. I feel a sense of joy and purpose I've never felt before, and have relationships with people in positive, trusting ways. Depression and anxiety are managed and life is manageable for the first time. I take better care of myself and have a more stable, balanced life - and fun! My husband sees a huge difference in me. This med has been a game-changer after trying 9 other antidepressants with little luck. Who knew life could be so good? And no sexual side effects. It has been a lifesaver and I would do whatever I have to to stay on it."
For Major Depressive Disorder "I have depression and panic disorder. I have been sick since I was 14. Now I am 48 years old. I have tried almost every antidepressant in my life. Trintellix is the best I have found for myself. Don't be afraid to try and don't give up. You will find what will help you! Good luck."
For Depression "Short and sweet— miracle drug for me. I have MDD and anxiety with panic attacks. This medication made me feel like myself again and did not cause any significant side effects. I’m pretty drug naive and I’d never been on a psychiatric drug until now. My life has significantly changed for the best. Please try this drug if you struggle with crippling anxiety that feeds your depression. I started off on a really tiny low dose since I’m super sensitive to medication, and any side effects were tolerable and went away within a week. Give this 2 months to work."
For Major Depressive Disorder "I've been on every antidepressant known to man. Trintellix is the only one that I can say works for me. I have no nausea. Sex drive hasn't changed, still good. I am able to do my job now. I am happy for the first time in 20 years."
For Depression "I can't understand the negative reviews. Have been on Celexa for 15 years and after taking Trintellix for a week... no comparison. Gentle, totally effective, no side effects, no fatigue nor cognitive impairment, great feeling of comfort and lack of anxiety. Fingers crossed but it sure works for me."
For Depression "This medication saved my life. I have tried several other drugs which did not help. Wellbutrin was the worst for me, giving me racing and really dark thoughts. Before taking any meds, I had an insane appetite and would wake up starving no matter how much I ate. In addition to excessive crying, feeling hopeless, not being able to do simple chores like shower. I went a few years suffering like this because I was in denial that I was depressed. Well fast forward a few years later after trying 3 different drugs at different strengths, and Trintellix is the one for me. I never thought I would sleep through the night again. I sleep so soundly now. My appetite is back to normal. My depressive thoughts have been tamed. I am so grateful for this drug and all it has done to improve my quality of life."
For Major Depressive Disorder "I've tried several other SSRIs for MDD. Lexapro had me puking every day. Prozac made me a zombie. Paxil gave me an energy boost and worked well, but I developed severe sexual side effects. Cymbalta seemed to be the best, but I got into a really bad funk and it just wasn't enough. After entering into counseling once the depression became debilitating, my therapist had me follow up with a psychiatrist. He switched me to Trintellix, and it is hands down the best drug I've tried. No side effects. He also put me on 10mg Dexedrine 3x a day for ADHD, which was previously untreated, and the combination has been amazing. I told my wife it's like jogging your whole life with ankle and wrist weights on and then all of a sudden someone removes them. That's the mental change I've felt on this drug combination. My depression scores have reduced from about 20-30 to 2 as of today. I hesitate to use the term 'miracle drug,' but it has definitely been an answer to prayer."
For Depression "My initial experience with Trintellix is very promising. I've suffered from treatment-resistant depression and Generalized Anxiety Disorder for many years. Name it, I've been on it. Many medicines flatlined me emotionally, others amped anxiety and left me sleepless, others were weight-sensitive, causing rapid weight gain (hello Remeron); others worked like a charm - until they stopped working. It's been a 25-year struggle. My new Doc put me on Trintellix, and within a few days, I felt more alert and 'content' with no sleeping problems. No side effects on the entry dose of 5 mg. I take 2.5 mg Klonopin when required if I have an anxiety peak - other than that I feel like the 'Me' I knew was in there."
For Major Depressive Disorder "This is the most gentle antidepressant I've ever taken. The first two weeks on this, I was very hungry, but that went away, and now I feel great. Virtually no side effects. I feel calm and happy. When I wake up, I'm not angry anymore, and I'm not down in the dumps. I'm taking 5 mg per day. I'm very happy with Trintellix."
For Major Depressive Disorder "Was on Cymbalta, dr put me on Trintellix 10mg. My depression was bad. All I wanted to do was stay in bed. I developed social anxiety. Wouldn’t go outside of my home. FINALLY I made a dr appt. My dr upped my dosage to 20mg. Feeling much better. I’ve only been on 2 weeks. I had not decorated for Christmas. I have 12 grandchildren who come to see us. We have a get-together on Christmas Eve, and it’s a big deal to them. I just didn’t care. After starting the 20mg it’s like something starting working again in my brain. I can’t explain it. I put my tree up, decorated it, decorated my house, went Christmas shopping, wrapped gifts, and was ready when all my children and my grandchildren came over Christmas Eve. We had a wonderful time. It’s like I was ME again! I was wondering if anyone else has had good results with Trintellix and how soon. I’m hoping it’s not a placebo effect. I was crying all the time before she upped my dosage to 20mg. Now I feel good to go!"
For Depression "Been on it for over a year. 10 mg daily. Best antidepressant for me ever! Tried them all & all with HORRIBLE constipation & other side effects. This is the only one that took care of my depression & didn't have any awful side effects other than a little nausea in the beginning. No weight gain, no decreased libido. It's definitely worth a try!"
"I am very sensitive to a lot of antidepressants,and I had tried a lot. I would spend countless hours reading reviews of each new antidepressant my doctor prescribed me, hoping something would work. So when I was prescribed this for OCD and GAD, I wasn't expecting much, since I mainly saw reviews for MDD and not my conditions. I initially started at a low dose and worked my way up to 20mg. It took 6 months on 20mg to feel 90% better. I have had GAD for over 20 years and just thought that is how I was. Then I was hit with really bad OCD in 2020 that caused severe distress. After finding Trintellix, I finally know what normal worrying is like and not obsessing over things/thoughts. I can finally sleep better too. I know everyone is different, but I felt hopeless and never believed reviews that said 'game changer.' But Trintellix was a game changer for me, and I hope this review brings hope for someone, especially for GAD and OCD."
For Depression "I have anxiety, OCD, and depression. I took this pill for a year, and it was the most amazing medication I had ever been on for my anxiety. I started low and took it at night to try and sleep away most side effects. But I did have diarrhea for the first 3 days of upping my dose, and I only went up to 10mg. But then it would go away, and I noticed a difference in my anxiety at 7.5mg, but I seriously was able to live my life, and I never knew what genuine happiness was until this medicine. However, after taking it for 6 months, I started to gain weight so fast. I gained 40 pounds in the following 6 months and then stopped taking it because it made me starving, I never felt full, and these kinds of meds are known to affect your metabolism in a bad way. So yes, this pill is amazing, but I got fat on it."
