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Generic Name: Xgeva (denosumab)

Xgeva Reviews

For Osteolytic Bone Metastases of Solid Tumors "I just had my third dose of Xgeva, I have them monthly for metastatic breast cancer. The first two times I had some lower back pain and minor aches and just feeling yucky for 24 hours. I had my third shot yesterday. I woke up after midnight in a lot of pain. My bones, muscles, and joints hurt. I was able to fall back to sleep but felt awful the next day and had more localized pain where my cancer is. When I related this to my doctor's nurse, she was surprised because she had never heard of this. I've read quite a few reviews of other patients experiencing the same thing. I'm uncertain as to continue taking this medication."


For Hypercalcemia of Malignancy "I have lung cancer with mets to bone. Two hours after the injection, I experienced the worst pain ever in my life! I walked into the infusion area without any body pain, just a very slight backache which Advil was helping, and 2 hours later I was crippled. It's 2 weeks now, and I'm either in a wheelchair or walking around the house with a cane. Horrible, horrible medication. I now take oxycontin every 12 hours and oxycodone every 3 hours. Refuse this drug if you are smart. Even my oncologist is 'surprised' with the side effects I have. I refuse to have a second injection of Xgeva."


For Osteolytic Bone Metastases of Solid Tumors "I have been on Xgeva for the last three years, I have breast cancer stage 3. I receive the shots every 3 months and I take a calcium pill every day. I don’t have pain from the Xgeva. I only get a burning sensation with the shot. If I feel cramping in my legs I eat a banana everyday. I don’t know how long it is effective? Does anyone else know how many years or how long you can take it or how long it is effective for?"


For Osteolytic Bone Metastases of Solid Tumors "I had been having injections of Xgeva for 7 months; I never had any difficulty - after my eighth injection, after two days I developed horrific pains at the sites of very old bone and joint injuries - I cannot explain why the difference - even my hands hurt! I am very reluctant to take ay more of this drug."


For Giant Cell Tumor of Bone "Took Xgeva for 2 year for Giant Cell Tumor of the spine. Doctor stopped it after 2 years because I was doing so well. Exactly Six months later the tumor came back. Now I'm on another round of treatments."


For Osteolytic Bone Metastases of Solid Tumors "I have prostate cancer that metastasized to the bone. This would be stage 4 prostate cancer. The prostate was removed by surgery 10 years earlier. I have been getting Xgeva injections for about 14 months. The pain I notice is in both upper legs and my low back. Pain could be from cancer or Xgeva. Just don't know. The back hurts a lot. I have learned to pre medicate with Alive or Tylenol about 2 hours before going to bed. This usually works. I go to bed without pain but it comes on as I lay in bed so I catch it early."


For Osteolytic Bone Metastases of Solid Tumors "I have been taking Xgeva for 1 1/2 years and the metastasis on my back has greatly improved with no side effects. I am taking vitamins C, D3, and Calcium. My oncologist and I are very satisfied so far. Thanks."


For Osteolytic Bone Metastases of Solid Tumors "Terrible side effects: bone pain, weakness, groin, and hip pain."

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  • Drug class: miscellaneous bone resorption inhibitors
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Patient resources

  • Xgeva drug information

Other brands

Prolia, Jubbonti, Wyost

Professional resources

  • Xgeva prescribing information
  • Denosumab (AHFS Monograph)

Other brands

Prolia

Related treatment guides

  • Osteolytic Bone Lesions of Multiple Myeloma
  • Giant Cell Tumor of Bone
  • Osteolytic Bone Metastases of Solid Tumors
  • Hypercalcemia of Malignancy