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Generic Name: Prometrium for Uterine Bleeding (progesterone)

Prometrium for Uterine Bleeding Reviews

"I am on 200 mg Prometrium due to uterus bleeding and enlarged uterus wall. Other than the bleeding, I had no post-menopause issues (I am 57 with high estrogen levels). After 2 days of taking the medication, bleeding stopped - great! After a few more days, I started gaining weight, breast tenderness, breast enlarging, very strange dreams every night, very tired during the day although I sleep at least 8 hours now, and bad headaches. Too many side effects for me. I went to my naturopathic doctor to do detailed hormone tests. Result = extremely high progesterone level. Make sure you get your hormones tested before taking the medication!"


"I'm 50 and developed simple hyperplasia. Went eight months without a period and then had a three-week period that was very heavy and sent me to the ER for hemorrhaging. The doctor put me on Prometrium 100 mg daily for three months. After just two pills, I was having panic attacks during the day and at night. Could not take it. Current endometrial lining is 8.4 mm after three weeks of bleeding, so likely will need a D&C. Will work with a naturopath to have some hormone testing done. It's likely that this dosage is just too high for me, but Prometrium doesn't come in a lower dose than 100 mg."


"My doctor is having me take this medication because I have excessive bleeding. So far, the bleeding has stopped, but I'm on day 10, and the side effects are kicking in. I have breast tenderness, stomach cramps, and it makes me very tired. Overall, so far it has done what it needs to do. I go off of it in 2 days, I'm hoping that my body will regulate."


"It saved my baby. I was showing signs of miscarrying because of my hormone levels. I took this for 12 weeks. The bleeding stopped the next day, and I now have a healthy little girl!"


"Helps bleeding. Makes asthma worse. Helps me sleep."

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Other brands

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Professional resources

  • Prometrium prescribing information
  • Progesterone (AHFS Monograph)

Other brands

Endometrin, Milprosa

Related treatment guides

  • Progesterone Insufficiency
  • Perimenopausal Symptoms
  • Endometrial Hyperplasia, Prophylaxis
  • Uterine Bleeding
  • Amenorrhea
  • Premature Labor