Generic Name: Tezspire for Asthma (tezepelumab)
"After injection, I experienced severe back pain, and pain in other joints began along with numbness and tingling in fingers, severe muscle contractions, balance and fine motor issues, weakness in my gait, and unable to raise arms over head."
"I have severe asthma, Pred high dependence, hospital admissions - nebulizers up to 8 a day, hospital drugs at home - coughing/wheezing, ruined my life. I am only 38! Used a wheelchair on and off for over 4 years. I wanted this drug so much, just had the 6th shot, they say because I have been so ill it will take the full year to feel good again. This drug is saving my life! Straight away less coughing - now fewer nebulizers, reducing steroids slowly but staying out of the hospital! Less wheezing, I will say by week 3 you feel it, wish it was every 3 weeks the shot. When I get the injection, I got a bad headache for a few days, I do get backache throughout the month, and some joint pain but that's absolutely nothing compared to not breathing every hour of the day. I choose to breathe! My asthma doesn't wake me up now, fewer drugs that ruled my life every hour of the day. I am planning some fun things now, I am excited for the future! This is why I am sharing my journey."
"Works great for about 2 1/2 weeks, but the effectiveness begins to wear off at about 2 1/2 - 3 weeks, and by the time of the next injection at 4 weeks come around, the coughing and rescue inhaler use rise dramatically. Injections should be every 3 weeks, not 4 weeks for best results."
"Tezspire has provided me with nothing but positive experiences. I have been taking Tezspire for more than two years with hardly any asthma symptoms. I was experiencing asthma attacks three or more times per week before taking this medication. I am very pleased with this medication."
"I take the Tezspire injection every four weeks at my asthma clinic and it has been a game changer for me! My asthma went into severe mode in 2020 and it put me into the hospital several times. The doc first tried Fasenra, which worked for the first injection, and then the next six, it did not help at all. Switched me to Tezspire, and I can now go back outside, smells don’t bother me anymore, and I feel like I can be active again. Just started my second year of taking it, and I couldn’t be more pleased with it… well, except for the cost!"
"My 12-year-old daughter has been taking Tezspire for 4 months, and the complete change in my daughter's quality of life has just been absolutely amazing. This is the fourth different injection medication that we have tried, and the best. I wish she could have gotten it sooner. I would recommend this to everyone. My daughter is finally getting to do things that she could not do for years!"
"I have had asthma since the age of 6. It was debilitating, and I frequently missed school for long periods of time. I only had relief at age 12 when a new class of drugs (rescue inhalers) became available, and I started allergy shots. So it was a horrific shock when, in my late 60s, severe asthma came back very suddenly and full force... once again, I was hunched over all day, wheezing, struggling for air... despite all the usual meds on hand. My doctor tried one of the new injectables, but it failed at the third month. Then we switched to Tezspire, and got great relief; I have been able to resume my normal daily activities, taking my other meds (inhaler as needed) and allergy shots."
"I was on another biologic for two years, and this medicine did more in three doses than the other did in two years. It's amazing, expensive with my insurance, but so very worth it. 32 years of severe asthma and now I almost feel like a different person. Can't wait to see what happens after this first year."
"Immediately reduced asthma symptoms as well as allergic rhinitis and sinusitis. I have experienced joint and tendon pain. Back pain, dry throat, dry eyes, some weight gain, and loss of hair or lack of hair growth."
"Have received two injections with a third one next week. Was skeptical of anecdotal stories from acquaintances, but after the initial injection, I had immediate relief from my respiratory issues. My allergy doctor suggested Tezspire after the treatments I currently used weren’t able to provide me the relief I was seeking. Works amazingly for me. I have noticed a recent change in how food tastes. Not sure if this is a side effect, but will bring this up to my doctor next week. Even if it is a side effect, I won’t stop the Tezspire injections. I haven’t felt this good in a long time."
"Have been using Tezspire for 6 months and it has changed my life. I have experienced significantly less asthma attacks since starting. I am able to exercise sometimes without the need for any pre/post-exercise reliever. However, there have been side effects. I usually experience a bad headache in the first 12 hours after taking the dose. I have also started getting back ache in the mornings. These side effects are absolutely worth the benefits of the medication in my opinion. I have noticed in the 4th week it feels as though it is wearing off."
"Only positive. I've personally not experienced any of the side effects listed... that I didn't already experience. I've experienced back and joint pain for most of my life since I was 11 years old because of Ehlers-Danlos Syndrome. So if the side effects aren't more prevalent than what I experience every day, then I wouldn't notice it. Since I got the disclaimer out of the way, here's why I like Tezspire: it reduces my allergic reaction to cannabis from attack inducing to mild irritation. Since no other allergy medication did anything for this, it's become a lifesaver for me since my state is about to legalize its use recreationally. So it might help others with other esoteric allergies as well. My only complaint about this medicine is that for me its effectiveness runs out before the 4th week is done. Otherwise, I'd recommend everyone who is still having problems with their asthma to try it under an allergist's supervision since there is a small chance of anaphylaxis."
"I just received my second dose of Tezspire today, but about 2 weeks after my first dose, my breathing was no longer labored, and the severe cough I had endured for the past several months became almost nonexistent."
"It has been amazing with a result in significant reduction in use of oxygen to no use for about 6 months. I was hospitalized 6 times and treated in the emergency room 4 times between the hospitalizations from August 2021 to August 2022 for COPD. I have COPD, but since 8/2022 the exacerbations have been few and symptoms are managed with oral medications and 2 daily inhalers. Is tinnitus a possible side effect?"
"This biologic is a strange thing. On the negative side, I cannot stand in one place longer than 5 minutes because my hips start hurting and I have to sit down. Also, during the night while I am sleeping my left knee will start hurting really bad for about a minute and then the pain goes away. Strange! I have not had any back issues, no sore throat nor any other side effects other than joint tightness so that's good. On the positive side, my asthma is so much better. I no longer cough in church, cold air doesn't bother me, but I still have to use my inhaler at night sometimes. Why? I don't know. I will get my third injection of Tezspire next week so I will see how it affects me...the same, better or worse."
"I found Tezspire works great for my asthma. Unfortunately, I developed a very bad cough on the second dose. I decided it was worth staying on, but after the third dose, the cough is crippling. The cough is so severe that I feel like it is choking me. Unfortunately, I will stop this medication. My asthma has been so good but I can’t live with a cough that keeps me up all night."
"It has helped with my allergies: dust, smoke, perfumes, and pet dander. During the first two days of my shot, I'd have some breathing problems. After that, all was good. When getting close to the next shot, I notice back pain, coughing, and sneezing starts back up. Waiting to take the third shot. I take 210mg every 4 weeks. Seems to wear off ten to 11 days before the next shot. Noticing I have not used my emergency inhaler since the second shot. That's a plus. Willing to give it a few more months to see what other results I may accomplish. For now, I rate it a five because I haven't been on it long enough."
"I started receiving monthly injections of Tezspire two years ago and together with Advair and sometimes prednisone, it worked well to control my asthma. However, the horrible side effect of Tezspire is that it makes you disabled. I cannot use my arms or my shoulders. It's terrible pain, I cannot sleep at night. I have to seriously talk to my doctor to stop Tezspire."
"I'm actually quite satisfied with Tezspire. My only complaint is that my asthma symptoms regress during the fourth week before my next dose. The effects of Tezspire start working in my system within an hour and suppress the worst of my asthma within 24 hours after getting my next injection. I'm not sure if it's the placebo effect or one of my other symptoms where many medications don't operate normally with me. This is well documented, but this is my only biological allergy shot that I get, so it can be for multiple different reasons."
"I developed a vaginal yeast infection after the injection as well as body odor. I never had this issue before. I am treating my yeast infection with other medications, but it is taking a bit to clear up. On the other hand, my allergies and asthma have gotten better, now I am able to sleep without having to have five pillows in my back to breathe. I tried Faserna, but it did not work on me. This one is working, but I am concerned about the vaginal infection."
"I began using after trying a different biological that didn't work for my reoccurring respiratory infections. After the initial month, I immediately noticed a change in my symptoms. My sinus symptoms began to disappear immediately. I began to use my rescue inhaler far less. I haven't had one sinus infection since I started Tezspire."
"I have only been on this med for 2 months. I immediately noticed a huge difference, I got my life back!"
"This worked so well that I went from asthma attacks every day to maybe one or two a month. It was a game changer and allowed me to live once again. It does have a body ache side effect."
"I am a lifelong severe asthmatic and just turned 53. I just took my 5th injection and have not looked for my rescue inhaler in over weeks. I hope these results continue."
"I was on everything with no success, including Nucala. Tezspire helped immediately with my upper and lower respiratory. Fortunate that Medicare pays for it."
