Estradiol / norethindrone for Postmenopausal Symptoms: Uses, Side Effects, Warnings, and Dosing Information

Generic Name: Estradiol / norethindrone for Postmenopausal Symptoms (estradiol-norethindrone)

Estradiol / norethindrone for Postmenopausal Symptoms Reviews

CombiPatch (estradiol / norethindrone) "I’ve been on this patch for a month and I feel like it saved my sanity! I was hot flashing constantly, had anxiety, brain fog, moodiness, and was exhausted. I finally feel normal again and got my life back. I might need this patch for the rest of my life, and I’m okay with that. I have had no side effects with this patch - thank God!"


Activella (estradiol / norethindrone) "I'm on Activelle for 8 years now, and it was the only HRT that makes me feel like my old self. I tried weaning myself off it, but then the hot flushes come back within a day. I would love not to use anything, but quality of life is very important to me, so I carry on. I tried every herbal and natural remedy, pill I could find, they only worked for perimenopause and not great at all. Two years I struggled every 4 weeks on a different HRT and wanted to jump off a building, until I went to see my gynecologist and she gave me Activelle. Even my family noticed that the old me was back. Why suffer, hey."


CombiPatch (estradiol / norethindrone) "I became menopausal about a year ago at 48 years old. Racked with hot flashes, mild loss of hair, thinning of skin, but mostly a total loss of humor and joy, I had to do something! I tried Equelle, and it did help with hot flashes, but that was it. Then I switched to several over-the-counter remedies which were more affordable. Nothing worked until the CombiPatch. I returned to my normal self. Sure, I had some mild bleeding, but that was nothing compared to the overall increase in quality of life—feeling better, sleeping better, and more energy overall. It is a lifesaver. It can be expensive if your insurance does not cover enough of the cost, but use the coupons for a reduction in cost. I highly recommend."


CombiPatch (estradiol / norethindrone) "I was on the CombiPatch for 6 weeks. After about 4 weeks, I began bleeding, not spotting, having a full period every 2 weeks like a regular period. 6 days prior to taking the patch, I was getting hot flashes that disrupted my life and caused me no sleep. After being on the patch, the flashes went away instantly, and I felt well, however, the heavy periods every 2 weeks were not worth it. It was too much to bear. My blood pressure went up a bit, and I had to change medications. A friend recommended that my doctor change the dosage, and yes, I had every exam in the book, even the intra-vaginal one (the medical term eludes me now) or sonogram, and all results were clear. My fibroids were 3cm, nothing unusual. I simply stopped using the patch and took it off. I couldn’t get to the doctor due to COVID constraints and everything being shut down. I haven’t had a period or spotting since then. I'm going back to the doctor when I can. Has anyone had the same experience?"


CombiPatch (estradiol / norethindrone) "I started the CombiPatch after suffering through night sweats, hot flashes, and sleeplessness for nearly seven years. I had no trouble falling asleep but would be wide awake at 3 AM for years, and I was always exhausted and frustrated by my interrupted sleep. I have been using the patch for five weeks and am already sleeping better and feel so much better. If I do wake up at 3 AM, I don't lie awake for hours anymore. I fall back to sleep and am DREAMING again! I love this patch and plan to stay on it for life!"


Activella (estradiol / norethindrone) "I am 52, and have been suffering from hot flashes for about 2 years. My doctor didn’t want to go the HRT route and prescribed me Clonidine at first. The Clonidine worked for about 4 months, then suddenly stopped. Hot flashes ramped up to 3-5 an hour! Sleep was near impossible. Finally, I was prescribed Activella LD. It took about 3 weeks to work, but it works. I am just 5 weeks in now. Zero hot flashes. I feel my moods have improved, and I also feel calmer. I am experiencing way less anxiety. Basically, I feel like I did 3 years ago before this menopause stuff all started. The only negative side effect for me is daily morning diarrhea, but that seems to be subsiding. I wish I had gotten this medication years ago."


CombiPatch (estradiol / norethindrone) "I am a registered nurse. I have been on CombiPatch for 10 years or so. I could not work without it. It made all the hot flashes and profuse sweating stop! Rare episodes of pinkish bleeding checked out and monitored. Hope I can continue to use it forever! Love this product! I am of normal weight, exercise regularly, and have never smoked."


CombiPatch (estradiol / norethindrone) "I had severe and constant hot flashes along with heart palpitations, syncope, and flushing, extreme anxiety and depression. It took 10 months to find a wonderful doctor who took me off of HRT oral and on CombiPatch, and it gave me my life back. I could actually feel myself calm down and feel better within 8 hours. No side effects, and yes, my gyno said I would probably be on it for life. That's fine with me, I am more about quality than quantity."


CombiPatch (estradiol / norethindrone) "I developed breast cancer after being on the CombiPatch for almost 3 years. Three of my cancer doctors believe the cancer was caused by the CombiPatch. There is no breast cancer in my family. I have had genetic testing and found out I have no genetic mutations that would have caused the cancer. Noven claims that the risks for breast cancer are low, but I do not believe it. There is nothing else in my history that would have caused the cancer. Please do not take this drug. If you are on it, get off of it and have regular mammograms. Self-examinations did not find my cancer. These pharmaceutical companies are taking advantage of women in pain trying to find relief from menopause. No drug should be sold that causes cancer."


Activella (estradiol / norethindrone) "On this medication for 3 weeks. I was waking up at least 2x nightly with hot flashes... The fatigue had gotten so bad there were mornings going to work I would cry in my car and wonder how I was going to make it through the day. My motivation to do anything was so low. Took this med a week, maybe less, and had my first full night's sleep and continue to do so - no hot flashes!! I also have noticed other benefits. I just feel better. I knew I didn't feel good some days, but all of this crept up so slowly I didn't realize how bad it had gotten for me. I'll watch for side."


CombiPatch (estradiol / norethindrone) "I have been using the patch for over 20 years, and my previous Dr. believed the benefits outweighed the risks. My present Dr. is more skeptical but lets me stay on it as long as I get yearly mammograms. When I went into menopause, the symptoms of extreme fatigue, moodiness, and hot flashes were horrible, and I decided I could not live that way. The patch is very expensive in the US. I have been buying it from Canada, where it is 1/3 the cost. I am also on the lowest dose and just using one patch a week. I will probably be on this for life."


Activella (estradiol / norethindrone) "I had experienced almost nonstop hot flashes for 3 years before asking my doctor for help. I was a mess. I am on the lowest dose of this medication, and it has been a lifesaver for me. Hot flashes gone, most of the irritability has gone away. I feel like my old self. It took about 3 weeks to notice the difference and have been taking it for 6 months now. I will have occasional breast pain, but it is nothing serious, just a twinge. Well worth the relief!"


CombiPatch (estradiol / norethindrone) "I have been using the CombiPatch for a week now for menopausal problems. I have had no side effects thus far. I did not have hot flashes, but had night sweats and severe moodiness. I was not a nice person all the time! I also experienced severe anxiety. This patch is very much helping me relax. I coupled the patch with Prozac. I just want to get back to normal!"


CombiPatch (estradiol / norethindrone) "Dr put me on 6 months back. Depression, anxiety, hot flashes n mood swings unbearable. It seemed to do the trick however had water retention and massive hair loss made me stop taking. Probably could have managed the water retention but the hair loss changed my mind to the point I started feeling and seeing bald patches, mounds of hair loss in drain (had very thick hair). Hair falling out non-stop, hair in car, laundry, running my hand through it."


CombiPatch (estradiol / norethindrone) "I've been on this patch For a month now. Within 2 weeks I started spotting. Within 3 weeks full on bleeding like I had as a 16 years old. Constant cramping of my thighs and uterus every day living on advil. My body does not seem to like any type of progesterone How do you determine biopsy negative. My doctor tells me to just keep wearing the patch my body will adjust is this true? And if so how long does this take I can't take much more of this. I will say all the menopause symptoms are completely gone but I'm bleeding cramping and have diarrhea every day so so where's the trade off?? Anybody help ° thank you"


CombiPatch (estradiol / norethindrone) "I was experiencing anxiety attacks, mood swings, strange electrical shocking sensations, and having trouble sleeping more than 2 or 3 hours at a time, even when I was exhausted. This is a pricey fix, but it immediately took care of my symptoms, but I'm having light periods occasionally. If I forget to change the sticker, those symptoms return. I'm on the low dose. I'm so thankful for this drug, while I am not a fan of drugs in general, this has definitely helped my quality of life."


CombiPatch (estradiol / norethindrone) "CombiPatch use to be amazing until they changed the transdermal material. Was once soft, pliable &, stayed in place no longer does. New material also causes a horrible rash now, a reaction. Medicine itself works great, no more hot flashes, hair loss or heart palpitations. Novum....Please go back to the original transdermal material. I cannot use with this change. Leaves permanent round burn scars where patch is placed"


Activella (estradiol / norethindrone) "Consider removal of ovaries if you use Activella or consider not taking it at at all. My mum was on the drug for several years and developed ovarian cancer. HRT increases risk of breast and ovarian cancer and I do not wish anyone to go through staff my mum is going through. Hot flushes are nothing compared to chemo and hight probability of death within next few months/years."


Activella (estradiol / norethindrone) "I have been taking Activella for 4 months now. It immediately alleviated hot flashing and anxiety/nervousness/irritability. However, I think it is beginning to cause headaches. I've also had scalp acne, which started when I was taking a generic form of Activella but seems to be clearing now that I'm taking the actual brand name of the drug. Also, I have noticed I am more emotional (tear up in a second) on this medicine. In the last month or so, I have become increasingly clumsy, dropping things I'm holding. Will update on this in 2 months."


CombiPatch (estradiol / norethindrone) "I am 54 years old and have had no period for about 2 years. My hot flashes were unbearable, also night sweats and trouble sleeping, anxiety - lots of issues. The CombiPatch has helped tremendously and in a short period of time. Feel like I have my life back to enjoy."


CombiPatch (estradiol / norethindrone) "Been on combipatch for about 12 years. Work like wonders. 6 months ago started to cut a sliver off every month but now can't sleep at night have vaginal astrophy etc. I've only been using a half patch and today I put the half back on. I feel like crap. Hope I can use it for a few more years. I'm 65 years old so it's rather scary."


CombiPatch (estradiol / norethindrone) "Started on the CombiPatch a few years ago and it saved my postmenopausal life. The hot flashes mood swings sleepless nights and everything else came to a halt and I felt normal again. My big concern is right now they are on back order until October 31st. I only have 2 left and we are trying to come up with an interim solution. Why does this company keep running out of the CombiPatch? Not great for your customers."


CombiPatch (estradiol / norethindrone) "I’m 48, been on combipatch for almost a year. For the first 6 months I was on the low dose - which was great and alleviated many symptoms: hot flashes, sleeplessness, anxiety, and weight gain in the midsection. I changed to the higher dose in May and felt great so I thought I could go back down to the lower dose in Sept., but that was a mistake. I just went back to the higher dose again and I’ll see how it goes in the winter. I did develop an allergic reaction to the adhesive but my dermatologist prescribed cortisone cream, I apply a bit to my skin and let it dry and the patch can be tolerated! Also, I do follow a lot of the Galveston Diet protocols and it helps immensely. I feel like I do a lot just to feel like myself, but it’s worth it."


CombiPatch (estradiol / norethindrone) "Started the patch one year ago, it took away my symptoms almost immediately...hot flashes, sleepless nights, electrical shock feelings, anxiety for no reason. I am very happy with it...the down side is that I'm bleeding like a light period a lot and have some breast pain. Getting that checked out soon."


CombiPatch (estradiol / norethindrone) "I was diagnosed with sudden Early menopause. Severe migraines (worst than I ever had), Anxiety and panic attacks, insomnia (barely sleeping), depression and night sweats. I really started feeling 90% better with-in a couple weeks. I’m sleeping. Anxiety is minimal and I’m sleeping again. Minimal side effects, but I’ve had bloating and bad indigestion."

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Related treatment guides

  • Postmenopausal Symptoms
  • Atrophic Vaginitis
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  • Hypoestrogenism

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